Listing code
114.06
Children (Part B)
Body system
114.00
Immune system disorders (children)
Subsections
2
Lettered criteria paths
Step in evaluation
3 of 5
Listing match approves the claim
SSA listing text and criteria
Undifferentiated and mixed connective tissue disease , as described in 114.00D5 . With involvement of two or more organs/body systems, and with:
Subsection A
One of the organs/body systems involved to at least a moderate level of severity; AND
Subsection B
At least two of the constitutional symptoms and signs (severe fatigue, fever, malaise, or involuntary weight loss). Back to Top
Source: SSA Blue Book listing 114.06. Last synced 2026-05-04.
Where claims under 114.06 usually fail
A common failure mode is missing the 'two or more organs/body systems' requirement, even if one system is very affected. Another failure is meeting symptoms but not the severity level: at least one involved system must be at least moderate in severity. Another pitfall is counting only one constitutional symptom from the allowed list, when the criteria require at least two of severe fatigue, fever, malaise, or involuntary weight loss. A related problem is focusing on organ symptoms without tying them to the constitutional symptom/sign requirements.
Medical evidence that strengthens this claim
Medical records should clearly identify undifferentiated or mixed connective tissue disease and list which organs or body systems are involved. Evidence should support 'at least moderate' severity for at least one involved organ or body system, and it should match how severity is described in the medical findings tied to the involved systems. Records should also document constitutional symptoms or signs with clear support for at least two of: severe fatigue, fever, malaise, or involuntary weight loss. Because immune system disorders in children can affect growth and age-appropriate activities through the disorder or its treatment, records that describe the child's overall condition alongside these symptoms can help connect the disease impact to the required criteria.
What happens if your records do not meet this listing
Step 4 is whether the child has impairments that lead to an 'extreme' limitation in functioning in activities of daily living, social functioning, and/or concentration, persistence, or pace, or 'marked' limitation in two of those areas. Step 5 considers whether the child's limitations, together with any medical-vocational factors, still result in a disability outcome even if the exact listing thresholds are not met. Many claims that miss the exact listing criteria still succeed later by showing the overall functional impact is equivalent to the listings' level of severity.
Work activity and the SGA gate for this condition
For any disability claim, the child must not be engaged in substantial gainful activity (SGA). Immune system disorders in children can cause extreme limitations through lesser degrees of limitation in two or more organs or body systems when paired with symptoms or signs such as severe fatigue, fever, malaise, or involuntary weight loss. This listing's structure requires both multi-system involvement and constitutional symptoms, so sustained work activity is not usually the focus for children, but the medical evidence should still show how the disorder affects functioning day to day.
Listing 114.06 FAQ
Questions that come up repeatedly for undifferentiated and mixed connective tissue disease , disability claims.