Listing code
110.06
Children (Part B)
Body system
110.00
Congenital disorders that affect multiple body systems (children)
Subsections
3
Lettered criteria paths
Step in evaluation
3 of 5
Listing match approves the claim
SSA listing text and criteria
Non-mosaic Down syndrome (chromosome 21 trisomy or chromosome 21 translocation), documented by:
Subsection A
A laboratory report of karyotype analysis signed by a physician, or both a laboratory report of karyotype analysis not signed by a physician and a statement by a physician that the child has Down syndrome (see 110.00C1 ). OR
Subsection B
A physician's report stating that the child has chromosome 21 trisomy or chromosome 21 translocation consistent with karyotype analysis with the distinctive facial or other physical features of Down syndrome (see 110.00C2a ). OR
Subsection C
A physician's report stating that the child has Down syndrome with the distinctive facial or other physical features and evidence demonstrating that the child is functioning at the level of a child with non-mosaic Down syndrome (see 110.00C2b ). Back to Top
Source: SSA Blue Book listing 110.06. Last synced 2026-05-04.
Where claims under 110.06 usually fail
Using a test that does not distinguish mosaic from non-mosaic (for example, fluorescence in situ hybridization) when the listing requires karyotype analysis. Having a karyotype report but it is not signed by a physician, without adding the required physician statement that the child has Down syndrome. Relying on a physician report that mentions chromosome 21 trisomy or translocation but not tying it to the karyotype analysis and the distinctive facial or other physical features described in the criteria. Trying to meet the criteria with evidence of Down syndrome and features but without the specific functional-level evidence required under the third option (functioning at the level of a child with non-mosaic Down syndrome).
Medical evidence that strengthens this claim
For subsection A, provide a copy of the karyotype analysis laboratory report signed by a physician, or provide an unsigned karyotype report plus a physician statement that the child has Down syndrome. Karyotype analysis is the definitive test used here, and SSA will not purchase karyotype analysis. For subsection B, include a physician report stating chromosome 21 trisomy or chromosome 21 translocation consistent with the karyotype analysis, along with the distinctive facial or other physical features of Down syndrome. For subsection C, include a physician report stating Down syndrome with distinctive facial or other physical features, plus evidence showing the child is functioning at the level of a child with non-mosaic Down syndrome.
What happens if your records do not meet this listing
This listing has three specific documentation routes (A, B, and C). When the required genetic proof and physician documentation do not match one of those routes, the case generally does not qualify under 110.06 based on this listing alone. However, step 4 and step 5 still allow a later approval if medical findings support a residual functional capacity (RFC) consistent with disability and the non-medical factors are met during the overall disability evaluation process. In practice for children, approvals may still happen even when one listing path is not fully satisfied.
Work activity and the SGA gate for this condition
For SSDI, work activity can affect whether a claim is considered at the early stages, but this listing is written for children under 18 and is tied to documentation of non-mosaic Down syndrome. SSA's disability-from-birth approach applies when non-mosaic Down syndrome is documented under 110.06A, 110.06B, or 110.06C. The criteria specifically reference chromosome 21 trisomy or chromosome 21 translocation and documentation such as karyotype analysis and physician reports. After approval, the usual trial work and extended eligibility concepts apply to SSDI beneficiaries (if applicable), but the listing itself does not change those general work-activity rules.
Listing 110.06 FAQ
Questions that come up repeatedly for non-mosaic down syndrome (chromosome 21 trisomy or chromosome 21 translocation), disability claims.