Body system 10.00 in the SSA Blue Book covers congenital disorders affecting multiple systems for adult (Part A). SSA uses these listings at step 3 of its five-step disability evaluation. If your medical evidence meets one of the listings on this page, your claim is approved without the disability examiner moving on to past-work and labor-market analysis at steps 4 and 5.
Most claimants who do not meet a listing in this body system can still be approved at later steps based on their residual functional capacity, age, education, and past work. The medical evidence you build for a listing-match argument is the same evidence those later steps rely on, so the listing criteria are useful to read even when a claim looks like a step-5 approval candidate.
Body system code
10.00
Part A
Active listings
1
Specific impairment
Audience
Adults 18+
SSA disability evaluation
Step in evaluation
3 of 5
Listing match approves the claim
Active listings under 10.00
Every listing below has current SSA-published criteria. Codes that SSA reserved for future use or has withdrawn since 1985 are not included. Click a listing where a plain-English breakdown is available, or follow the regulation link for SSA's exact text.
| Code | Listing | Reference |
|---|---|---|
| 10.06 | Non-mosaic Down syndrome, (chromosome 21 trisomy or chromosome 21 translocation), | ssa.gov |
Source: SSA Blue Book, body system 10.00. Last synced 2026-05-04.
How SSA describes this body system
Excerpted from SSA's regulatory introduction at the top of the body-system page. Full text and all subsection cross-references live on ssa.gov.
A. Which disorder do we evaluate under this body system ? Although Down syndrome exists in non-mosaic and mosaic forms, we evaluate only non-mosaic Down syndrome under this body system. B. What is non-mosaic Down syndrome? Non-mosaic Down syndrome is a genetic disorder. Most people with non-mosaic Down syndrome have three copies of chromosome 21 in all of their cells (chromosome 21 trisomy); some have an extra copy of chromosome 21 attached to a different chromosome in all of their cells (chromosome 21 translocation). Virtually all people with non-mosaic Down syndrome have characteristic facial or other physical features, delayed physical development, and intellectual disability. People with non-mosaic Down syndrome may also have congenital heart disease, impaired vision, hearing problems, and other disorders. We evaluate non-mosaic Down syndrome under 10.06 . If you have non-mosaic Down syndrome documented as described in 10.00C , we consider you disabled from birth. C. What evidence do we need to document non-mosaic Down syndrome under 10.06 ? 1. Under 10.06A, we will find you disabled based on laboratory findings. a. To find that your disorder meets 10.06A , we need a copy of the laboratory report of karyotype analysis, which is the definitive test to establish non-mosaic Down syndrome. We will not purchase karyotype analysis. We will not accept a fluorescence in situ hybrid...
Read the full text on the SSA Blue Book 10.00 page.
What happens during a claim under 10.00
The disability examiner assigned to your claim looks for medical records that match the lettered criteria of one of the listings above. The examiner does not diagnose you and does not weigh symptoms in isolation. They line up the listing's required findings against your records and decide whether the records contain enough to satisfy the listing as written.
If your records meet a listing, the claim is approved at step 3. If not, the examiner moves on to evaluating your residual functional capacity (RFC) at steps 4 and 5. RFC is a description of what work activity you can still do despite your impairments. The listings inform the RFC because the same medical evidence the listings ask for is the evidence the examiner uses to write the RFC. The disability overview walks through the full five-step evaluation in plain English.
Work activity, SGA, and the SSDI gate
A claim under any Blue Book listing is denied at step 1 if you are working at or above the substantial gainful activity threshold. SGA is the monthly earnings test SSA applies before any medical evaluation. Earning above SGA in countable work activity means SSA never reaches the listings on this page. Earning below SGA, or being out of work entirely, lets the medical evaluation proceed.
Once you are approved and receiving SSDI, the trial work period and extended period of eligibility apply differently than at the initial-application stage. Both are explained on the SGA amount page with year-by-year thresholds since 1975.
Children's listings for the same body system
SSA publishes a parallel body system at 110.00 for the children's (under 18) side of the same conditions. Many listings cross over with tighter functional thresholds for the children's version. The Congenital disorders that affect multiple body systems (children) page covers the 2 active listings on that side.