Listing code
10.06
Adult (Part A)
Body system
10.00
Congenital disorders that affect multiple body systems
Subsections
3
Lettered criteria paths
Step in evaluation
3 of 5
Listing match approves the claim
SSA listing text and criteria
Non-mosaic Down syndrome, (chromosome 21 trisomy or chromosome 21 translocation), documented by:
Subsection A
A laboratory report of karyotype analysis signed by a physician, or both a laboratory report of karyotype analysis not signed by a physician and a statement by a physician that you have Down syndrome (see 10.00C1 ). OR
Subsection B
A physician's report stating that you have chromosome 21 trisomy or chromosome 21 translocation consistent with prior karyotype analysis with the distinctive facial or other physical features of Down syndrome (see 10.00C2a ). OR
Subsection C
A physician's report stating that you have Down syndrome with the distinctive facial or other physical features and evidence demonstrating that you function at a level consistent with non-mosaic Down syndrome (see 10.00C2b ). Back to Top Support Contact us Find an office Forms Publications Report fraud Languages Español Other languages Plain language Services for Employers & businesses Government agencies Other groups Representatives About Careers Chief actuary data Communications Financial reports Initiatives Research & policy Social Security Administration <svg fill="currentCol
Source: SSA Blue Book listing 10.06. Last synced 2026-05-04.
Where claims under 10.06 usually fail
Missing the karyotype requirement for 10.06A is a frequent failure mode, including submitting a test other than karyotype when the goal is to distinguish non-mosaic from mosaic. Another pitfall is having a karyotype report that is not signed by a physician without also providing the additional physician statement required under 10.06A. Some claims get stuck on 10.06B by describing the facial or physical features without the physician report that is specifically consistent with prior karyotype analysis for chromosome 21 trisomy or chromosome 21 translocation. For 10.06C, a common miss is having the Down syndrome and physical-feature documentation but not including the evidence demonstrating functioning at a level consistent with non-mosaic Down syndrome.
Medical evidence that strengthens this claim
For 10.06A, the key document is a copy of the karyotype analysis laboratory report, signed by a physician. If the karyotype report is not signed by a physician, the file also needs a physician statement that the person has Down syndrome (10.06A). For 10.06B, documentation needs a physician report stating chromosome 21 trisomy or chromosome 21 translocation consistent with prior karyotype analysis, plus the physician report describing distinctive facial or other physical features of Down syndrome. For 10.06C, it needs distinctive facial or other physical features plus physician documentation of Down syndrome along with evidence demonstrating functioning at a level consistent with non-mosaic Down syndrome. FISH is not accepted for establishing non-mosaic versus mosaic status.
What happens if your records do not meet this listing
If 10.06 is not met under the exact documentation path in 10.06A, 10.06B, or 10.06C, SSA evaluates disability using the usual step process that can include assessing residual functional capacity (RFC). Practically, many claims that do not meet a listing still succeed later if the overall medical evidence supports a level of functional limitation that prevents substantial work. The listing is considered a high bar for diagnosis documentation, while other evidence routes may still support a favorable finding later in the evaluation.
Work activity and the SGA gate for this condition
For SSDI, the SGA rule is applied at the start of the claim process, and work activity can affect whether a claim can be decided based on earnings level. Under this specific congenital listing, if documentation satisfies 10.06A, disability is considered from birth. For people whose documentation fits 10.06C, SSA also considers evidence of functioning at a level consistent with non-mosaic Down syndrome, which is directly tied to the listing criteria. After approval, trial work and the period for continued eligibility operate as they do for other impairments, but the medical-activity limits implied by the listing criteria are what generally matter for whether continued work is realistic during these periods.
Listing 10.06 FAQ
Questions that come up repeatedly for non-mosaic down syndrome, (chromosome 21 trisomy or chromosome 21 translocation), disability claims.