Body system 14.00 in the SSA Blue Book covers immune system disorders for adult (Part A). SSA uses these listings at step 3 of its five-step disability evaluation. If your medical evidence meets one of the listings on this page, your claim is approved without the disability examiner moving on to past-work and labor-market analysis at steps 4 and 5.
Most claimants who do not meet a listing in this body system can still be approved at later steps based on their residual functional capacity, age, education, and past work. The medical evidence you build for a listing-match argument is the same evidence those later steps rely on, so the listing criteria are useful to read even when a claim looks like a step-5 approval candidate.
Body system code
14.00
Part A
Active listings
9
Specific impairments
Audience
Adults 18+
SSA disability evaluation
Step in evaluation
3 of 5
Listing match approves the claim
Active listings under 14.00
Every listing below has current SSA-published criteria. Codes that SSA reserved for future use or has withdrawn since 1985 are not included. Click a listing where a plain-English breakdown is available, or follow the regulation link for SSA's exact text.
| Code | Listing | Reference |
|---|---|---|
| 14.02 | Systemic lupus erythematosus | ssa.gov |
| 14.03 | Systemic vasculitis | ssa.gov |
| 14.04 | Systemic sclerosis (scleroderma) | ssa.gov |
| 14.05 | Polymyositis and dermatomyositis | ssa.gov |
| 14.06 | Undifferentiated and mixed connective tissue disease | ssa.gov |
| 14.07 | Immune deficiency disorders, excluding HIV infection | ssa.gov |
| 14.09 | Inflammatory arthritis | ssa.gov |
| 14.10 | Sjögren's syndrome | ssa.gov |
| 14.11 | Human immunodeficiency virus (HIV) infection | ssa.gov |
Source: SSA Blue Book, body system 14.00. Last synced 2026-05-04.
How SSA describes this body system
Excerpted from SSA's regulatory introduction at the top of the body-system page. Full text and all subsection cross-references live on ssa.gov.
A. What disorders do we evaluate under the immune system disorders listings? 1. We evaluate immune system disorders that cause dysfunction in one or more components of your immune system . a. The dysfunction may be due to problems in antibody production, impaired cell-mediated immunity, a combined type of antibody/cellular deficiency, impaired phagocytosis, or complement deficiency. b. Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body's own tissues. Immune system disorders can cause a deficit in a single organ or body system that results in extreme (that is, very serious) loss of function. They can also cause lesser degrees of limitations in two or more organs or body systems, and when associated with symptoms or signs, such as severe fatigue, fever, malaise, diffuse musculoskeletal pain, or involuntary weight loss, can also result in extreme limitation. c. We organize the discussions of immune system disorders in three categories: Autoimmune disorders; Immune deficiency disorders, excluding human immunodeficiency virus (HIV) infection; and HIV infection. 2. Autoimmune disorders ( 14.00D ). Autoimmune disorders are caused by dysfunctional immune responses directed against the body's own tissues, resulting in chronic, multisystem impairments that differ in clinical manifestations, course, and outcome. They are som...
Read the full text on the SSA Blue Book 14.00 page.
What happens during a claim under 14.00
The disability examiner assigned to your claim looks for medical records that match the lettered criteria of one of the listings above. The examiner does not diagnose you and does not weigh symptoms in isolation. They line up the listing's required findings against your records and decide whether the records contain enough to satisfy the listing as written.
If your records meet a listing, the claim is approved at step 3. If not, the examiner moves on to evaluating your residual functional capacity (RFC) at steps 4 and 5. RFC is a description of what work activity you can still do despite your impairments. The listings inform the RFC because the same medical evidence the listings ask for is the evidence the examiner uses to write the RFC. The disability overview walks through the full five-step evaluation in plain English.
Work activity, SGA, and the SSDI gate
A claim under any Blue Book listing is denied at step 1 if you are working at or above the substantial gainful activity threshold. SGA is the monthly earnings test SSA applies before any medical evaluation. Earning above SGA in countable work activity means SSA never reaches the listings on this page. Earning below SGA, or being out of work entirely, lets the medical evaluation proceed.
Once you are approved and receiving SSDI, the trial work period and extended period of eligibility apply differently than at the initial-application stage. Both are explained on the SGA amount page with year-by-year thresholds since 1975.
Children's listings for the same body system
SSA publishes a parallel body system at 114.00 for the children's (under 18) side of the same conditions. Many listings cross over with tighter functional thresholds for the children's version. The Immune system disorders (children) page covers the 9 active listings on that side.