Listing code
14.06
Adult (Part A)
Body system
14.00
Immune system disorders
Subsections
2
Lettered criteria paths
Step in evaluation
3 of 5
Listing match approves the claim
SSA listing text and criteria
Undifferentiated and mixed connective tissue disease . As described in 14.00D5 . With:
Subsection A
Involvement of two or more organs/body systems, with: 1. One of the organs/body systems involved to at least a moderate level of severity; and 2. At least two of the constitutional symptoms or signs (severe fatigue, fever, malaise, or involuntary weight loss). OR
- One of the organs/body systems involved to at least a moderate level of severity; and
- At least two of the constitutional symptoms or signs (severe fatigue, fever, malaise, or involuntary weight loss). OR
Subsection B
Repeated manifestations of undifferentiated or mixed connective tissue disease, with at least two of the constitutional symptoms or signs (severe fatigue, fever, malaise, or involuntary weight loss) and one of the following at the marked level: 1. Limitation of activities of daily living. 2. Limitation in maintaining social functioning. 3. Limitation in completing tasks in a timely manner due to deficiencies in concentration, persistence, or pace. Back to Top
- Limitation of activities of daily living.
- Limitation in maintaining social functioning.
- Limitation in completing tasks in a timely manner due to deficiencies in concentration, persistence, or pace. Back to Top
Source: SSA Blue Book listing 14.06. Last synced 2026-05-04.
Where claims under 14.06 usually fail
One common miss is having disease in more than one area but not meeting the threshold structure of the criteria, meaning only one organ/body system is shown as moderate severity and the constitutional symptom requirement (at least two of severe fatigue, fever, malaise, involuntary weight loss) is not documented. Another pitfall is counting constitutional symptoms incorrectly, like relying on mild tiredness without documentation of severe fatigue, or missing the involuntary aspect of weight loss. A third failure mode is using the wrong option: Subsection B requires repeated manifestations plus at least two constitutional symptoms and one marked functional limitation (activities of daily living, social functioning, or timely task completion tied to concentration, persistence, or pace).
Medical evidence that strengthens this claim
Strong documentation matches the lettered structure: evidence of involvement of two or more organs or body systems, plus clear severity level for at least one organ/body system (moderate) for Subsection A. For the constitutional symptom requirement, medical records should show at least two of the specified constitutional symptoms, chosen from severe fatigue, fever, malaise, or involuntary weight loss. For Subsection B, documentation should show repeated manifestations of undifferentiated or mixed connective tissue disease and also show at least two constitutional symptoms, plus one marked limitation category: limitation of activities of daily living, limitation in maintaining social functioning, or limitation in completing tasks in a timely manner due to deficiencies in concentration, persistence, or pace.
What happens if your records do not meet this listing
If the criteria are not met under 14.06 Subsection A or B, the claim still can be decided using steps that consider what the condition allows the person to do despite symptoms. SSA looks at residual functional capacity (RFC) and then applies the medical-vocational evaluation process to decide whether there is work that can be done given the functional limits. Many claims that miss a Blue Book listing still get approved later if the overall functional effects are severe enough when translated into work-related abilities.
Work activity and the SGA gate for this condition
At the start of an SSDI claim, work activity has to be evaluated under the substantial gainful activity (SGA) rules before disability is considered. For this condition specifically, the listing's focus on constitutional symptoms (severe fatigue, fever, malaise, involuntary weight loss), multisystem involvement (two or more organs/body systems with at least one at moderate severity), and marked functional limits (activities of daily living, social functioning, or timely task completion tied to concentration, persistence, or pace) gives a sense of the level of overall impairment SSA is requiring in the listing pathway. If approved, the usual work rules still apply under the trial work period and the extended period of eligibility for SSDI beneficiaries, but the specific SGA threshold dollar amount is not part of the listing criteria here.
Listing 14.06 FAQ
Questions that come up repeatedly for undifferentiated and mixed connective tissue disease disability claims.